Lott became president of Lott Oil Company in 1979 and has helped build it from a single truck and two employees to one of the region’s most successful petroleum distributorships. The company delivers more than 100 million gallons of fuel and three million gallons of commercial lubricants to Louisiana and adjoining states. Lott Oil was a key responder during Hurricane Katrina, delivering the first diesel for generators to the command posts set up by FEMA and the Coast Guard in downtown New Orleans. The company remains a vital team member in disaster response planning with state and parish emergency services and law enforcement.

Lott is a leader in his profession, serving on the National Advisory Board for Chevron-Texaco, as vice president of the Chevron Texaco Petroleum Marketers Association and former president of the Louisiana Oil Marketers and Convenience Stores Association. He has also been involved in public service and in local civic organizations.

Lott is a decades-long supporter of Northwestern State athletics and the Demons Unlimited Foundation. In 2017, he and his family established the Luther W. Lott, Sr. Memorial Scholarship, an endowed four-year scholarship through the NSU Foundation. Through his leadership Lott Oil is a long-time supporter of numerous charitable organizations.